IMP1 3′ UTR shortening enhances metastatic burden in colorectal cancer
نویسندگان
چکیده
منابع مشابه
Economic burden of colorectal cancer in Iran in 2012
Background: Colorectal cancer is one of the most common cancers in Iran. However little is known about the economic burden associated with this cancer in Iran. The aim of this study was to estimate the economic burden of colorectal cancer in Iran in the year 2012. Methods: We used the prevalence-based approach and estimated direct and indirect costs of all color...
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3'-Untranslated region (UTR) shortening of mRNAs via alternative polyadenylation (APA) has important ramifications for gene expression. By using proximal APA sites and switching to shorter 3'-UTRs, proliferating cells avoid miRNA-mediated repression. Such APA and 3'-UTR shortening events may explain the basis of some of the proto-oncogene activation cases observed in cancer cells. In this study...
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1 Abad A, Garcia P, Gravalos C, et al. Sequential methotrexate, 5-fluorouracil (5-FU), and high dose leucovorin versus 5-FU and high dose leucovorin versus 5-FU alone for advanced colorectal cancer. A multi-institutional randomized trial. Cancer 1995; 75: 1238–44. 2 Ajani JA, Kanojia MD, Bedikian AY. High-dose methotrexate and 5-fluorouracil in patients with advanced colorectal carcinoma. A ran...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2018
ISSN: 0143-3334,1460-2180
DOI: 10.1093/carcin/bgy153